Most of these studies suggest that cerebrospinal fluid (CSF) biomarkers, most prominently CSF neurofilament light (NfL), Tau, amyloid β42, chitinase 3-like proteins 1 and 2, and immunoglobulin (Ig) G oligoclonal bands (OCBs), may predict CI in MS, thus providing some insights into the mechanisms underlying the deterioration of specific cognitive domains (15). The gene discussed is NEFL; the disease is myeloid sarcoma.