CXCR3 predominantly recruits Th1 cells by interacting with CXCL10 and is upregulated on CD3+ T cells in the peripheral blood, on CD8+ T cells in the aqueous humor, in oral ulcers on mononuclear cells in the skin and in intestinal lesions of patients with BD (12, 33, 38, 44). This evidence concerns the gene CD8A and Behcet disease.