TPM4 and dermatomyositis: Their team has found that IL-18 was the only elevated cytokine in DM lesions, and that IL-18 combined with the expression of LCE2D (late cornified envelope 2D), LCE1B (late cornified envelope 1B), KRT80 (keratin 80) and TPM4 (Tropomyosin 4) to clearly differentiate DM from CLE lesions (151).