Their team has found that IL-18 was the only elevated cytokine in DM lesions, and that IL-18 combined with the expression of LCE2D (late cornified envelope 2D), LCE1B (late cornified envelope 1B), KRT80 (keratin 80) and TPM4 (Tropomyosin 4) to clearly differentiate DM from CLE lesions (151). The gene discussed is IL18; the disease is dermatomyositis.