TIMP1 and enteritis: We also induced normal colon mucosa NCM460 cells to transform into enteritis cells through LPS, and found that after 24 hours of induction, enteritis cells could secreted higher inflammatory factor IL-1β and IL-8 (Figure 5E), and the expression levels of CCL3, MMP3 and TIMP1 in enteritis cells were significantly up-regulated, which were consistent with the expression in the above tissues (Figure 5F).