In addition, CCL3, MMP3, and TIMP1 expression were negatively correlated with tumor purity in colon cancer (P = 2.30e-8, cor = -0.273; P = 6.68e-5, cor = -0.196 and P = 7.41e-16, cor = -0.385, respectively). The gene discussed is TIMP1; the disease is malignant colon neoplasm.