CGAS and neoplasm: Another study showed that the ionizing radiation (IR)-induced DNA damage repair (DDR) inhibitor AZD6738 in combination with RT and ICIs in HCC led to stronger immunologic memory, lasting antitumor immunity than radioimmunotherapy, and the prevention of tumor recurrence in mouse models, which relied on the activation of the cyclic GMP-AMP synthase/stimulator of interferon genes (cGAS/STING) signaling pathway (82).