In a murine E. coli lung inflammation model, it has been demonstrated that 15-epi-LAX4 and 17-epi-RvD1 signal through the ALX/FPR2 receptor on PMN to inhibit Toll-like receptor 9-mediated release of neutrophil elastase (NE) and proteinase 3 (PR3). This evidence concerns the gene ELANE and inflammatory response.