In lipid families, eicosanoids have special profiles in aging mice and AD patients (Valcarcel-Ares et al., 2019; Duro et al., 2022), and cholesterol ester (CE) can aggregate in triggering receptor expressed on myeloid cells 2 (TREM2) KO and AD-variant human iPSC microglia (García-Sanz et al., 2021; Magno et al., 2021). The gene discussed is TREM2; the disease is Alzheimer disease.