In 6-OHDA-induced rat and chronic 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mouse models, acetyl-l-carnitine can protect the immunoreactivity of TH and DTA in the nigral-striatal system, and slow PD progression (Afshin-Majd et al., 2017; Burks et al., 2019). This evidence concerns the gene TH and Parkinson disease.