Previously, we showed that deletion of Foxo1 in the lymphatic endothelium induces new lymphatic valves to grow, which rescues the lymphatic valve defects in the Foxc2 heterozygous mice, a mouse model of lymphedema-distichiasis, by increasing the number of valves and by enhancing the function of valves. The gene discussed is FOXC2; the disease is Distichiasis.