MAPT and tauopathy: This is essential as overexposure of the PAD is linked to multiple tauopathies (Kanaan et al., 2011; Kanaan et al., 2016; Combs and Kanaan, 2017) and overexpression of 6D tau, an N-terminal tau construct that cannot fold, in primary hippocampal neurons results in axon degeneration (Morris 2021).