ACTN1 and head and neck squamous cell carcinoma: In addition, ACTN1 expression was also high in HNSCC cells and downregulation of ACTN1 could also suppress cell proliferative, migrative and invasive abilities as well as EMT in HNSCC, and reduce the tumor growth in xenograft tumor mice, which was in line with the role of ACTN1 in other tumors.