CTLA4 and atherosclerosis: Poels et al. (69) also conducted a study on the effect of antibody-mediated CTLA-4 inhibition on experimental atherosclerosis in Ldlr−/− mice aged 6–8 weeks fed a 0.15% cholesterol diet for 6 weeks and treated with 200 μg CTLA-4 antibody every 2 weeks.