In the management of mild to moderately symptomatic COVID-19 patients, several trials have reported the possible adjuvant effect of oral curcumin supplementation, including speedy clearance of the SARS-CoV-2 in the RT-PCR test, early resolution of the COVID-19-associated acute symptoms, increase in oxygen saturation level, reduction in serum CRP levels, increase in lymphocyte count, reduction in duration of supplemental oxygen and hospitalization period (48–53). The gene discussed is CRP; the disease is COVID-19.