Although overexpression of TREM2 is correlated with poorer prognosis in multiple tumors, including gastric, hepatic, and ovarian carcinoma, TREM2 has been shown to suppress tumorigenesis of hepatic carcinoma, in experimental models of hepatic carcinoma in the context of liver fibrosis [19]. The gene discussed is TREM2; the disease is hepatocellular carcinoma.