CASP3 and breast cancer: Earlier reports emphasized the anti-breast cancer activity of carotenoids by inhibiting proliferation and inducing apoptosis in breast cancer cell lines such as MCF7 and MDAMB 231 through up-regulation of ROS, DNA fragmentation, caspase 3 activation, Bcl 2 down-regulation, and by modulating other important cellular pathways (Black et al., 2020; Koklesova et al., 2020; Saini et al., 2020), but breast cancer-specific receptor targeting is not well known.