TTR and amyloidosis: Whilst successful in patients with early-onset p.(V50M)-associated ATTRv amyloidosis who typically have ATTR-PN without ATTR-CM (31), liver transplantation in patients with established ATTRv-CM did not prevent ongoing deposition of wild-type ATTR amyloid deposits on top of the existing template of variant ATTR cardiac amyloid resulting in poor outcomes (32).