Although many studies have assessed the association between PON1Q192R polymorphism and CAD in the European populations, as far as we know, no study has investigated the association between CAD (based on Gensini and SYNTAX score) and the mentioned polymorphism in the Iranian ethnicity, so the present study aimed to examine the association of the PON1 Q192R polymorphism with CAD and cardiometabolic risk factors in Iranian patients suspected of CAD. Here, PON1 is linked to coronary artery disorder.