MLH1 alterations were present in 15 patients overall, most commonly in the STS cohort (n=13), including four patients with undifferentiated pleomorphic sarcoma, three patients with sarcoma NOS, two patients with rhabdomyosarcoma, two patients with intimal sarcoma, one patient with leiomyosarcoma, and one patient with a radiation-associated sarcoma. The gene discussed is MLH1; the disease is undifferentiated pleomorphic sarcoma.