Subgroup analysis revealed that the downregulation of ITGβ3 in tumor tissues was a risk factor for reduced one-year Overall Survival(OS) (log-rank p = 0.050, HR = 2.29 (1.00–5.37); Figure 2B) and five-year OS (log-rank p = 0.032, HR = 1.99 (1.06–3.79); Figure 2C) in patients with COAD (Table 2). Here, ITGB3 is linked to colon adenocarcinoma.