Importantly, this study revealed that tumor growth suppression by MMP-14 blockade was associated with reduced immunosuppressive TGF-β and the shift of macrophages to anti-tumor M1 phenotype, while improved vascular function and tissue oxygenation by MMP inhibition-induced increase in tumor inducible nitric oxide synthase led to increased radiation response in MMP-14-high-expressing tumors. Here, MMP14 is linked to neoplasm.