TIMP2 and endothelial dysfunction: Tumor cell-derived TIMP-2 was shown to induce endothelial dysfunction and promote transmigration of breast cancer cells across vascular endothelial monolayers through the activation of endothelial MMP-2 in the presence of active MMP-14, suggesting the role of TIMP-2/MMP-14/MMP-2 pathway during metastasis (122).