Soluble MMP-14 derived from bone marrow-derived stromal cells promoted the migration of luminal A breast cancer cells by inducing endoglin (transforming growth factor-β [TGF-β] auxiliary receptor) shedding on the breast cancer cell surface, suggesting a pro-tumorigenic role of stromal MMP-14 (94). The gene discussed is TGFB1; the disease is breast carcinoma.