Sox10 acts as a transcription factor to promote the expression of UGT8, which significantly promotes ceramide metabolism leading to sulfatide formation and thus increases the binding of integrin αVβ5 to activate the TGF-β and NF-κB pathways in basal-like breast cancer to encourage its capacity to spread and migrate (38) (Figure 3). This evidence concerns the gene UGT8 and breast carcinoma.