UGT1A6 and cancer: UGTs genes are upregulated in tissues associated with drug metabolism, such as cancers of the liver, kidney, intestine, and pancreas, such as UGT1A6, UGT1A9, UGT1A10, UGT2A3, UGT2B7, and UGT8, and they are significantly associated with increased overall survival in cancer (9).