Analysis of postmenopausal women with osteoporosis revealed that UGT1A1*28 can be used as a marker of bone loss for the timely assessment of bone tissue changes, and that pureton mutations in UGT1A1*28 can reduce the risk of bone loss and osteoporosis in postmenopausal women (25, 61). The gene discussed is UGT1A1; the disease is osteoporosis.