Figure S2B illustrated that in HPA database, IRF1, IRF3, IRF7-9 were upregulated in tumour, while the opposite is true for IRF6. IRF2 was highly expressed in both tissues. IRF4 and IRF5 were low or undetectable in both tissues. Furthermore, we observed that IRFs were highly correlated in expression (Figure 1F) and interacted with each other in PPI network (Figure 1G). Here, IRF2 is linked to neoplasm.