MELK and neoplasm: Despite the small sample size of N=98 stage I-III TCGA samples with available primary tumor gene expression, we noted a trend of the association of high MELK expression [dichotomized using the optimal expression threshold to best separate the KM curves from the Human Protein Atlas (46)] with less favorable CM survival (median OS=2.25 years in MELK high expressors vs OS=3.71 years in MELK low expressors; log-rank p=0.059; Figure 2B).