IL4 and experimental autoimmune encephalomyelitis: Although there is no human study on the effect of retinol derivative therapy in the acute phase of MS, in rats with experimental autoimmune encephalomyelitis as an animal model of MS, supplement therapy with vit A metabolites, namely ATRA showed reduced expression of T-bet, IFN-γ, increased level of GATA3 and IL-4 gene expression, and down modulated TH17 differentiation leading to accelerated recovery and better clinical outcome (24).