In addition, in human breast cancer cell lines, neutrophils can secrete the cytokine oncostatin-M (OSM) under the induction of granulocyte-macrophage colony stimulating factor (GM-CSF), and OSM promotes vascular endothelial growth factor (VEGF) expression and increases the invasive ability of tumor cells (23, 24). The gene discussed is VEGFA; the disease is neoplasm.