In this study, medulloblastoma upregulates ligands of NK cell-activating receptors such as NKG2D and natural cytotoxic receptors (NCRs), thereby inducing NK cell-mediated cytotoxicity and medulloblastoma cell apoptosis, demonstrating the feasibility and safety of intraventricular infusion of autologous NK cells. The gene discussed is KLRK1; the disease is medulloblastoma.