reported that MSU stimulation-activated NLRP3 inflammasome, macrophages deficient in NLRP3, and ASC or caspase-1 were defective in IL-1β secretion in response to MSU, deficiency of ASC, or caspase-1 impaired the neutrophil influx in an animal model of MSU-induced peritonitis (11). The gene discussed is CASP1; the disease is peritonitis.