With the discovery that NLRP3 inflammasome mediates caspase-1 activation and IL-1β maturation, its relation with insulin resistance and type 2 diabetes development has been recognized (13, 95–97); NLRP3 deficiency protects mice from obesity-induced insulin resistance (13, 96). Here, NLRP3 is linked to obesity due to melanocortin 4 receptor deficiency.