Moreover, a variety of sterile danger signals in tissues, which induce chronic inflammation also activate NLRP3, so NLRP3 inflammasome is central to the pathogenesis of many chronic inflammatory diseases such as gout, type 2 diabetes, non-alcoholic steatohepatitis (NASH), atherosclerosis, and Alzheimer’s disease (AD) (9–13). Here, NLRP3 is linked to early-onset autosomal dominant Alzheimer disease.