TG and bacterial infectious disease: Because the Tg+ neonates (5-10 days old) exhibit robust type 1 inflammation with spontaneous bacterial infection and, on the other hand, the Tg+ adults exhibit robust muco-obstructive phenotype with almost no bacterial infections, we employed juvenile mice (3-week-old) that exhibit most of the hallmarks of Tg+ lung disease, i.e., bacterial infections, muco-obstructive, mucous cell metaplasia, and mixed granulocytic inflammation of Tg+ mice (26, 28–30).