Therefore, we conducted a case-control association study examining eight non-HLA candidate loci (3 SNVs for PTPN22 rs2476601, rs1217412, rs2488457 and 5 for CTLA-4 rs3087243, rs231775, rs5742909, rs4553808 and rs733618) in north Indian adult AIH patients. The gene discussed is CTLA4; the disease is autoimmune hepatitis.