CD8A and neoplasm: In tumor models, studies have shown that α-Galcer-loaded tumor cells induce a strong antitumor immunity along with memory cytotoxic T-lymphocyte (CTL) generation in a DC-dependent manner (87) as well as a recent popular therapeutic avenue, CAR-iNKT cells, which present superior antitumor effects along with the generation of antitumor central memory CD8+ T cells (81).