Besides, Mitochondrial protein mitofusion 2 (Mfn2) plays an important role in connecting ER membranes to mitochondria and mitochondrial fusion, studies show that hepatic mfn2 deficiency impairs ER-mitochondrial phosphatidylserine transfer and mitochondrial function, leading to ER stress and liver inflammation in NAFLD (57, 58). Here, MFN2 is linked to metabolic dysfunction-associated steatotic liver disease.