Moreover, ectopic expression of Sip3 in the fat body reversed the reductions in Drs and Mtk transcript levels by loss of Sip3 upon infection (Figures 1I, J), implying that the E3 ligase Sip3 controls the activation of Toll signaling post bacterial stimuli primarily through its essential role in the fat body. The gene discussed is GEMIN7; the disease is infection.