Nonetheless, NLRP3 macrophages differentiated into CXCL Macros, which were only found in high tumor stages and featured the highest activity of the hypoxia-related regulons HIF1A and CREB and their target genes downstream including VEGFA and CXCL1/3/5/8 (88, 89). The gene discussed is CXCL1; the disease is neoplasm.