IL4 and atopic eczema: Additionally, fisetin suppresses the production of cytokines and chemokines such as interferon-gamma (IFN-γ) and interleukin-4 (IL-4) by activated CD4+ T cells, reduces IL-31 by stimulated mast cells, and enhances the production of the anti-inflammatory cytokine, IL-10 in atopic dermatitis-like (AD) mouse models (32, 33).