Aberrant autophagy has been reported in both atopic dermatitis and psoriasis patients and TNFα treated KCs (122) and associated with accrual of p62/SQSTM1, which is destroyed during autophagic process, an indication that the processing of the cargo is hampered already even during the enhancement of the onset of autophagosome formation (122). The gene discussed is TNF; the disease is psoriasis.