PDCD1 and glaucoma: In summary, we found that PD-1 prevented ganglion cell injury in a mouse COHT model, participated in the dynamic regulation of M1/M2-like microglia, we also found a new breakthrough point for the study of neuroimmunological mechanisms in glaucoma-induced RGC apoptosis, and identified a novel target for the neuroprotective treatment of glaucoma-related RGC injury.