VPS39 and carcinoma: Although we did not measure the vam6 expression and mTORC1 activation in human intratumoral iNKT cells, published scRNA-seq data of colorectal liver metastases (CRLM) patients from other group (31) show a slightly increase of Vam6 and impaired mTORC1 activation in intratumoral CD27+ iNKT cell cluster, in comparison with cells in para-carcinoma tissues (Supplementary Figure 7).