Moreover, we found that NK cells in lungs of mice received expanded Vam6+/− iNKT cells produced more granzyme B than those cells in mice received expanded Vam6+/+ iNKT cells, despite similar level of granzyme B in CD8 T cells, indicating a contribution of NK cells in enhanced tumor clearance in lung metastasis models (Figures 7N, O). The gene discussed is VPS39; the disease is neoplasm.