Consistently, in those B16F10 tumor-bearing Jα18-/- chimeric mice, α-GC induced less IFN-γ and IL-4 production in intratumoral CD45.2+Vdac1+/- iNKT cells, despite their normal granzyme B production (Supplementary Figures 5C, D). The gene discussed is IFNG; the disease is neoplasm.