Besides, traits association analysis (see Supplementary Table 1) showed that 3 SNPs (rs62394289 in the SLC17A3 gene, rs9378220 in TRIM31, rs112733823 in LINC00243) were associated with other potential risk factors of stroke (high blood pressure and Rheumatoid arthritis) and therefore, were also excluded. This evidence concerns the gene TRIM31 and hypertensive disorder.