IL10 and Other metabolic disease: Numerous studies have demonstrated that L. reuteri can mitigate experimental colitis by maintaining intestinal immune homeostasis through stimulating dendritic cell maturation and IL-10 production (38, 39), modulating gut microbiota and metabolic disorders (40), increasing mucus thickness and tightening epithelium (41), and decreasing bacterial translocation from mucosa to mesenteric lymph nodes (42, 43).