LRG1 is an acute-phase protein related to inflammation-associated diseases and is known to be involved in protein-protein interaction, signal transduction, and cell adhesion (58). It promotes wound repair and keratinocyte migration via HIF-1α stability regulation (59). However, it also promotes melanoma dissemination via EGFR/STAT3 signaling regulation (60). The gene discussed is LRG1; the disease is melanoma.