PTEN and neoplasm: Pten, a famous tumor suppressor gene that controls a wide range of cellular functions such as survival, proliferation, energy metabolism, and cellular architecture (Song et al., 2012), had been reported to be regulated by the splicing factor SRSF3, whose downregulation could cause the use of proximal PAS of Pten and finally lead to cellular senescence (Shen et al., 2019).