Next, we built an aging-related risk signature of pancreatic cancer patients, and the risk score formula was as follows: risk score = 0.01893*GSK3B + 0.01203 * SERPINE1 + 0.21210 *PLAU +0.00538* TOP2A-0.21165 *GDF11 + 0.29423 * EPS8 + 0.04018 * BUB1B + 0.16445 * FEN1-0.16805* HIC1 + 0.01571 * NOG-0.03386 * EPOR-0.09390 * TRPV1 + 0.01691* HOXC4-0.08234* GH1. The gene discussed is TOP2A; the disease is pancreatic neoplasm.