BUB1B is the hub gene of pancreatic ductal adenocarcinoma (PDAC), and the expression of BUBR1 encoded by BUB1B can predict poor prognosis in pancreatobiliary-type tumors (Gladhaug et al., 2010; Dong et al., 2019). The gene discussed is BUB1B; the disease is pancreatic ductal adenocarcinoma.