UNC93B1 and neoplasm: These classical innate immune cells (macrophages, DCs, neutrophils, Basophils, Eosinophils, Mast cells and NK cells) (Bandyopadhaya et al., 2016) offers an alternative immunotherapeutic option to attack tumor cells, and targeting TLRs or metabolism signaling dysregulated by UNC93B1 might be an effective treatment too.