As we demonstrated in Figure 3B, another signaling enriched by UNC93B1 were metabolic pathways, and AML blasts might switch from BCL2-dependence to MCL1-dependence to drive energy metabolism under specific circumstances (Pei et al., 2020), we next focused on expression of BCL2 and MCL-1 in AML. The gene discussed is UNC93B1; the disease is acute myeloid leukemia.