UNC93B1 and acute myeloid leukemia: As we all known, AML subtype M4-with eosinophilia (M4-eo) is classified by AML blasts with inv (16) that have a myelomonocytes with immature basophilic granules (Sangle and Perkins, 2011), which is consistent with our results that UNC93B1 is higher in M4/M5 FAB subtypes leukemia.