Genetic knockout (KO) of TRIM69 significantly inhibited tumor development, as evidenced by the decreased growth rate, weight and size of tumors from mice inoculated with the sg.TRIM69-transduced S-1 and C-2 cells in comparison to those from mice that were inoculated with the sg.TRIM69-nontransduced cells, respectively (Figure 6C and Supplemental Figure 6E and F). The gene discussed is TRIM69; the disease is neoplasm.