For instance, TRIM65 facilitates ubiquitylation of trinucleotide repeat containing adaptor 6A (TNRC6A), downregulating expression of miR-138-5p and conferring the ATG7-mediated chemoresistance in non-small-cell lung cancer (NSCLC) 33. This evidence concerns the gene TNRC6A and non-small cell lung carcinoma.