Although the S-1 or C-2 transfectants stably expressing EYA4 were still tumorigenic in vivo, both the tumor growth rate and mass from mice inoculated with these transfectants were much slower and smaller than those in mice that were inoculated with the transfectants expressing EV or transfectants coexpressing EYA4 plus TRIM69 (Figure 5J and Supplemental Figure 5C and D), respectively. Here, TRIM69 is linked to neoplasm.