EYA4 and cancer: To identify potential E3 ligase (s) responsible for EYA4 turnover within PDAC cells in an unbiased manner, we conducted a cancer cell line encyclopedia (CCLE)-based screening approach to compare RNA sequencing data of 40 E3 ubiquitin ligases in a panel of 12 pancreatic carcinoma cell lines for identifying the candidate whose expression is inversely correlated with EYA4.