PELI2, an isoform of pellino homolog E3 ligase that has a central role in initiating formation of NACHT, LRR and PYD domains-containing protein 3 (NLRP3) inflammasome indispensable for adaptive immune suppression in pancreatic cancer 24, 25, was found to be positively correlated with EYA4 but to a lesser extent than SIAH1 (r = 0.597, P = 0.041). Here, NLRP3 is linked to familial pancreatic carcinoma.