We validated the prognostic model using an external validation dataset from TCGA, selecting mRNA sequencing (mRNA-seq) and miRNA-seq data for OSCC (including laryngeal and hypopharyngeal cancers) and screening the matrix data for SLC20A1, PITX2, hsa-mir-135b, hsa-mir-377, and hsa-let-7c. This evidence concerns the gene PITX2 and hypopharynx cancer.