In this study, we identified a combination of 14 TFs (NOTCH3, NR5A1, WDR5, RARB, SRCAP, SMAD3, ONECUT1, PITX3, TRAF6, MTA2, JDP2, FOSL1, GLI1, MTF1) and effectively predicted RFS in GC patients using the univariate Cox proportional hazard analysis, the LASSO Cox regression analysis, and multivariate Cox proportional hazard analysis. Here, PITX3 is linked to gastric cancer.