Finally, 14 TFs (NOTCH3, NR5A1, WDR5, RARB, SRCAP, MTA2, ONECUT1, PITX3, TRAF6, SMAD3, JDP2, FOSL1, GLI1, MTF1) were found to be significantly related to RFS in GC patients by multivariate Cox analysis. The gene discussed is TRAF6; the disease is gastric cancer.