The two aspects seem contradictory, and the specific mechanism of CTNNA1 in intestinal adenomas is not fully understood, and hence, further investigation of the relationship between CTNNA1 and K-Ras, phosphatase and tensin homolog (PTEN) 14, Wnt, MAPK/PI3K, and TGF-β 15 in colorectal cancer is warranted. Here, PTEN is linked to colorectal cancer.