HAVCR1 and acute kidney injury: Al-Kuraishy et al. revealed that BBR has no significant effect on AKI biomarkers except on serum kidney injury molecules (KIM-1) in diclofenac-induced AKI, whereas combined use of BBR and pentoxifylline significantly reduced renal biomarkers such as blood urea, serum creatinine, and glomerular filtration rate (eGFR) [35].