SOD1 and amyotrophic lateral sclerosis: Nine broad ontological categories of aberrant physiological functions have been defined in SOD1 G93A ALS mice (Mitchell and Lee, 2012a) and used to guide ALS pharmaceutics (Pandya et al., 2013): apoptosis, axonal transport, cellular chemistry, biological energetics, neuron excitability, inflammation, oxidative stress, proteomics, and systemic function.