We compared the age, sex, education level, eGFR, HD duration, whether with high blood pressure history, whether with diabetes history, blood pressure and blood glucose levels, peripheral blood serum Fe content and hemoglobin (Hb) content, and plasma Aβ40, Aβ42, Tau, pTau181 concentration, Aβ42/Aβ40 ratio, neurocognitive assessments such as MMSE, logical memory test-20-minutes delayed, VFT, digit span test, clock drawing test, stroop color, and word test C. Among them, the Aβ42/Aβ40, blood glucose levels, and VFT score difference between the two groups is statistically significant (Table 2). Here, GSTM1 is linked to blood pressure trait.