At this juncture, GAT-1 is not alone: many other - by now prominent - examples of diseases unequivocally linked to mutations in the SLC6 protein family, include chronic orthostatic intolerance, infantile parkinsonism/dystonia, hyperekplexia and creatine transporter deficiency in the human transporters for norepinephrine (NET, SLC6A2), dopamine (DAT, SLC6A3), glycine (GLYT-2, SLC6A5) and creatine (CRT-1, SLC6A8), respectively (Asjad et al., 2017a; El-Kasaby et al., 2019; Farr et al., 2020; Bhat et al., 2021). This evidence concerns the gene SLC6A5 and hyperekplexia.