While light and melatonin are commonly used to treat circadian misalignment, another behavioral method used to reinforce the internal biological clock is time-restricted feeding, which can dramatically increase robustness of the peripheral clocks, delay diet-induced metabolic disease, and promote healthy aging (Hatori et al., 2012; Chaix et al., 2014, 2019; Acosta-Rodríguez et al., 2022). The gene discussed is CLOCK; the disease is metabolic disease.