SPAG17 and major depressive disorder: In the PGC (Psychiatric Genomics Consortium) and iPsych consortiums, among 32,408 MDD cases and 109,946 controls using a significance threshold of 5 × 10−7, a genome-wide SNP-by-sex interaction study found two significant interactions for MDD on chromosome 1p12 and 17q21 [SPAG17, ZNF385C] and a significant interaction for recurrent MDD on chromosome 1p12 [SPAG17] [36].